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KMID : 1199120100340020095
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Korean Diabetes Journal
2010 Volume.34 No. 2 p.95 ~ p.100
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Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients
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Kim Eun-Hee
Yu Ji-Hee
Lee Sang-Ah
Kim Eui-Young
Kim Won-Gu
Lee Seung-Hun
Cho Eun-Hee
Koh Eun-Hee
Lee Woo-Je
Kim Min-Seon
Park Joong-Yeol
Lee Ki-Up
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Abstract
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Background: Serum cystatin C level is a more sensitive marker of renal dysfunction than serum creatinine level. Serum cystatin C level was recently reported to predict the development of cardiovascular disease. This study was performed to evaluate whether the cystatin C level is associated with coronary artery disease (CAD), independent of diabetic nephropathy.
Methods: We conducted a case-control study to assess the relationship between serum cystatin C level and coronary artery disease in diabetic patients. Among 460 diabetic patients, 38 diabetic patients had CAD. The control group consisted of 38 diabetic patients who were matched to cases by age, sex, and presence/absence of diabetic nephropathy. Serum cystatin C level was measured in stored samples.
Results: Serum cystatin C level was significantly higher in patients with diabetic nephropathy, both in CAD and non-CAD patients. However, serum cystatin C level did not differ between CAD and non-CAD patients, regardless of diabetic nephropathy.
Conclusion: Serum cystatin C level is a marker of renal dysfunction, but not coronary artery disease, in diabetic patients.
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KEYWORD
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Cystatin C, Coronary artery disease, Diabetic nephropathies, Diabetes mellitus
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